Inhibition of Escherichia coli RecA by rationally redesigned N-terminal helix.
نویسندگان
چکیده
Bacterial RecA promotes the development and transmission of antibiotic resistance genes by self-assembling into an ATP-hydrolyzing filamentous homopolymer on single-stranded DNA. We report the design of a 29mer peptide based on the RecA N-terminal domain involved in intermonomer contact that inhibits RecA filament assembly with an IC50 of 3 microM.
منابع مشابه
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 5 10 شماره
صفحات -
تاریخ انتشار 2007